clsA [2017-03-31 14:40:38]

cardiolipin synthase, major enzyme

locus: BSU36590

pI: 9.55

mw: 55.70 kDa

protein length: 482 aa

gene length: 1446 bp

function: biosynthesis of phospholipids

product: cardiolipin synthase, major enzyme

essential: no

synonyms: ywnE

Genomic Context

categories

• [category|SW 2|Metabolism] → [category|SW 2.4|Lipid metabolism] → [category|SW 2.4.2|Biosynthesis of lipids] → [category|SW 2.4.2.2|Biosynthesis of phospholipids]
• [category|SW 6|Groups of genes] → [category|SW 6.2|Membrane proteins]

Gene

Coordinates: 3,762,664 -> 3,764,112

Phenotypes of a mutant

• increased conjugation of ICEBs1 [Pubmed|26833415]

The protein

Catalyzed reaction/ biological activity

• 2 Phosphatidylglycerol = diphosphatidylglycerol glycerol (according to Swiss-Prot)

Protein family

• Cardiolipin synthase subfamily (according to Swiss-Prot)

Paralogous protein(s)

• [protein|07752EC6940F43DEBD1E9313A2A195E35EDB9F69|YwiE], [protein|B63AAF0D3277FD776944A09D2546F3E48C8716AD|YwjE]

[SW|Localization]

• cell membrane at the septum, this localization depends on two C-terminal helices [Pubmed|26708983,15743965]

Biological materials

Mutant

• MGNA-A198 (ywnE::erm), available at the [https://shigen.nig.ac.jp/bsub/resource/strainGeneDisrupted/detail/198 NBRP B. subtilis, Japan]

References

• 18820022,14973018,16514141,15743965,26708983,26833415

Expression and Regulation

Operons

• genes: [gene|2079B210322F26EEC3CCF55611622FADDB1D1BC7|clsA]
  description: [Pubmed|22383849]